Augmenting the articular cartilage-implant interface: Functionalizing with a collagen adhesion protein
نویسندگان
چکیده
منابع مشابه
Collagen of articular cartilage
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
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The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
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Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular phenotype. The nascent type II collagen fibril is a heteropolymer, with collagen IX molecules covalently linked to the surface and collagen XI forming the filamentous template of the fibril as a whole. The functions of collagens IX and XI in the heteropolymer are far from clear but, evidently, th...
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The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens. In the articular cartilages of adult joints, type III collagen makes an appearance in varying amounts superimposed on the original collagen fibril network. In a study to understand be...
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The proteoglycan meshwork is deemed to be the main source of resistance to fluid flow in articular cartilage. Maroudas (1968) showed that the decrease in proteoglycan volumetric fraction from the tidemark (bone-cartilage interface) to the articular surface corresponds to an increase in permeability from tidemark to surface, which is consistent with the well accepted “proteoglycan paradigm”. How...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2012
ISSN: 1549-3296
DOI: 10.1002/jbm.a.34144